Through her artistic practice, Ghada Amer constantly aims to upend the traditional hierarchies of painting, and engage with the intentional reorientation of gaze through a feminist lens. She is greatly influenced by French feminist thinkers such as Helene Cixous, who wrote the famous 1975 essay “The Laugh of the Medusa” and advocated for women creating their own language and writing about their own experience in order to transform themselves from object to subject. In Homage à Tut, Amer has appropriated an image of a woman from a pornographic magazine, and imbued its subject with a kind of authority that defies its original context. This work was featured in the Metropolitan Museum of Art's exhibition, Flight into Egypt: Black Artists and Ancient Egypt, 1876–Now (November 17, 2024–February 17, 2025).

Amer’s works have been exhibited at a wide variety of institutions including the Museum of Modern Art in New York, the Whitney Biennial, the Venice Biennale, the Brooklyn Museum, the Smithsonian National Museum of African Art in Washington, D.C., the Centre Georges Pompidou in Paris, the Garage Center for Contemporary Culture in Moscow, among others. Her works can be found in the collections of the Art Institute of Chicago, the Brooklyn Museum, the Centre Georges Pompidou, the Museo Jumex in Mexico City, the Crystal Bridges Museum of Art in Arkansas, the Guggenheim Abu Dhabi, the Museum of Arts and Design in New York, and the Leeum, Samsung Museum in Seoul, among others.